Vikas Dudeja Selected Research

Diterpenes

1/2019	Pre-clinical evaluation of Minnelide as a therapy for acute myeloid leukemia.
5/2017	Minnelide Inhibits Androgen Dependent, Castration Resistant Prostate Cancer Growth by Decreasing Expression of Androgen Receptor Full Length and Splice Variants.
1/2017	Downregulation of Sp1 by Minnelide leads to decrease in HSP70 and decrease in tumor burden of gastric cancer.
1/2017	Modulation of post-translational modifications in β-catenin and LRP6 inhibits Wnt signaling pathway in pancreatic cancer.
5/2015	Primary and liver metastasis-derived cell lines from KrasG12D; Trp53R172H; Pdx-1 Cre animals undergo apoptosis in response to triptolide.
6/2014	Triptolide sensitizes pancreatic cancer cells to TRAIL-induced activation of the death receptor pathway.
6/2014	Triptolide activates unfolded protein response leading to chronic ER stress in pancreatic cancer cells.
9/2013	miR-204 mediated loss of Myeloid cell leukemia-1 results in pancreatic cancer cell death.
10/2012	A preclinical evaluation of Minnelide as a therapeutic agent against pancreatic cancer.
10/2007	Triptolide induces pancreatic cancer cell death via inhibition of heat shock protein 70.

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Vikas Dudeja Research Topics

Disease

48	Neoplasms (Cancer) 01/2022 - 01/2007
46	Pancreatic Neoplasms (Pancreatic Cancer) 10/2022 - 01/2007
15	Pancreatitis 06/2022 - 01/2007
11	Adenocarcinoma 01/2022 - 01/2007
9	Neoplasm Metastasis (Metastasis) 01/2022 - 10/2007
5	Necrosis 01/2018 - 01/2007
4	Inflammation (Inflammations) 06/2022 - 12/2011
4	Tics (Tic) 11/2019 - 05/2014
4	Stomach Neoplasms (Stomach Cancer) 01/2017 - 01/2011
3	Chronic Pancreatitis 06/2022 - 05/2013
3	Pancreatic Diseases (Pancreatic Disease) 01/2018 - 03/2008
3	Neuroblastoma 04/2013 - 08/2009
2	Idiopathic Pulmonary Fibrosis 06/2022 - 01/2022
2	Pain (Aches) 06/2020 - 01/2018
2	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 09/2019 - 01/2019
2	Hepatocellular Carcinoma (Hepatoma) 03/2019 - 04/2016
2	Melanoma (Melanoma, Malignant) 01/2018 - 01/2018
2	Colonic Neoplasms (Colon Cancer) 01/2018 - 06/2015
1	Atrophy 06/2022
1	Fibrosis (Cirrhosis) 06/2022
1	Weight Loss (Weight Reduction) 01/2022
1	Malnutrition (Nutritional Deficiencies) 01/2022
1	Steatorrhea 01/2022
1	Ascites 01/2022
1	Circulating Neoplastic Cells 01/2021
1	Disease Progression 01/2021
1	Mucinous Adenocarcinoma (Mucinous Carcinoma) 01/2021
1	Uterine Cervical Neoplasms (Cancer of the Cervix) 01/2021
1	Pneumonia (Pneumonitis) 07/2020
1	Venous Thromboembolism 07/2020
1	Heart Arrest (Cardiac Arrest) 07/2020
1	Diabetes Mellitus 06/2020

Drug/Important Bio-Agent (IBA)

27	triptolideIBA 01/2022 - 10/2007
20	14-O-phosphonooxymethyltriptolide disodium saltIBA 01/2022 - 10/2012
12	Proteins (Proteins, Gene)FDA Link 05/2021 - 03/2008
10	DiterpenesIBA 01/2019 - 10/2007
8	CeruletideIBA 06/2022 - 04/2007
8	ProdrugsIBA 01/2021 - 11/2013
6	Pharmaceutical PreparationsIBA 06/2022 - 05/2014
5	HSP70 Heat-Shock Proteins (Heat-Shock Protein 70)IBA 01/2021 - 01/2007
5	Small Interfering RNA (siRNA)IBA 01/2019 - 01/2007
4	Arginine (L-Arginine)FDA Link 06/2022 - 04/2007
4	Transcription Factors (Transcription Factor)IBA 01/2018 - 12/2011
4	CaspasesIBA 06/2015 - 01/2007
3	CytokinesIBA 06/2022 - 01/2007
3	Caspase 3 (Caspase-3)IBA 01/2021 - 02/2010
3	Peptides (Polypeptides)IBA 01/2020 - 01/2012
3	EnzymesIBA 01/2019 - 06/2014
3	NF-kappa B (NF-kB)IBA 11/2017 - 04/2013
3	TrypsinogenIBA 10/2014 - 12/2011
2	CollagenIBA 06/2022 - 01/2016
2	pirfenidoneIBA 06/2022 - 01/2022
2	Opioid Analgesics (Opioids)IBA 06/2020 - 01/2018
2	transporter associated with antigen processing (TAP)IBA 01/2020 - 01/2019
2	AntigensIBA 01/2020 - 01/2019
2	Hyaluronic Acid (Hyaluronan)IBA 01/2020 - 01/2016
2	Endoplasmic Reticulum Chaperone BiPIBA 12/2019 - 01/2018
2	Peroxidase (Myeloperoxidase)IBA 10/2019 - 07/2008
2	Sp1 Transcription FactorIBA 07/2019 - 11/2013
2	folfirinoxIBA 01/2019 - 01/2016
2	Enzyme Precursors (Zymogens)IBA 01/2019 - 01/2007
2	TrypsinIBA 01/2019 - 10/2016
2	ATP-Binding Cassette Transporters (ABC Transporters)IBA 12/2018 - 01/2018
2	CalciumIBA 01/2017 - 05/2009
2	RNA (Ribonucleic Acid)IBA 11/2016 - 01/2012
2	Cathepsin BIBA 10/2016 - 01/2012
2	Annexin A5IBA 05/2015 - 01/2007
2	DNA Nucleotidylexotransferase (Terminal Deoxynucleotidyl Transferase)IBA 05/2015 - 09/2010
2	LigandsIBA 06/2014 - 02/2010
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 06/2014 - 02/2010
2	Death Domain ReceptorsIBA 06/2014 - 02/2010
2	Heat-Shock Proteins (Heat-Shock Protein)IBA 08/2009 - 03/2008
2	QuercetinIBA 05/2009 - 01/2007
2	Messenger RNA (mRNA)IBA 03/2008 - 01/2007
2	Cholecystokinin (Pancreozymin)IBA 04/2007 - 01/2007
1	Interleukin-10 (Interleukin 10)IBA 01/2022
1	VitaminsIBA 01/2022
1	Paclitaxel (Taxol)FDA LinkGeneric 01/2022
1	Cytokine Receptors (Cytokine Receptor)IBA 05/2021
1	Gamma Secretase Inhibitors and ModulatorsIBA 01/2021
1	HexosaminesIBA 01/2020
1	Immune Checkpoint InhibitorsIBA 01/2020
1	Fatty Acids (Saturated Fatty Acids)IBA 12/2019
1	Glucose (Dextrose)FDA LinkGeneric 12/2019

Therapy/Procedure

29	Therapeutics 06/2022 - 08/2009
14	Drug Therapy (Chemotherapy) 01/2022 - 01/2007
5	Pancreatectomy 07/2020 - 08/2013
4	Neoadjuvant Therapy 01/2022 - 09/2013
4	Radiotherapy 12/2019 - 07/2010
4	Lymph Node Excision (Lymph Node Dissection) 01/2019 - 01/2011
3	Immunotherapy 01/2021 - 01/2018
3	Injections 01/2018 - 08/2009
2	Enzyme Replacement Therapy 10/2022 - 01/2022
2	Autologous Transplantation 06/2020 - 08/2013
2	Gastrectomy 02/2012 - 01/2011
1	Chemoradiotherapy 01/2021
1	Heterologous Transplantation (Xenotransplantation) 01/2021
1	Minimally Invasive Surgical Procedures 07/2020
1	Artificial Respiration (Mechanical Ventilation) 07/2020
1	Contraindications 06/2020